The outlook for children, adolescents and young adults living with cystic fibrosis (CF) has changed enormously in the past two decades due to significant changes in clinical practice over this period. It is important for Endocrinologists, finding themselves in this new landscape, to understand the implications of novel therapeutics and altered clinical trajectories on the management of Endocrine disorders. This session will explore some of the changes in CF care including CFTR modulator therapies on bone health, and glycaemia.