Monday, 14th November ESA-SRB-APEG-NZSE 2022

Time: 7:00 - 8:00am, breakfast served from 6:40am

Presentation title: Growing pains: Dilemmas in the management of growth disorders.

Speaker: Professor Wayne Cutfield

Synopsis: Professor Wayne Cutfield will lead an interactive case based presentation that will explore management dilemmas across a variety of growth conditions. This will include genetic testing in short stature disorders, who, when, how? Growth hormone treatment in young adults with Prader Willi Syndrome, what are the benefits and risks? Apparent non-responders to growth hormone treatment, what next?

Professor Cutfield has served for many years as an elected member of the KIGS International Executive Scientific Committee which was responsible for KIGS analyses, presentations and publications.

• Improving the Diagnostic Accuracy and Treatment Decisions in  the Face of Changing Epidemiology of Hypogonadism in Men - Shalender Bhasin
• Improving outcomes with diabetes technology from early childhood to young adulthood: 4T Study - David Maahs

• Activin A levels regulate fetal testicular macrophages in mice - Samira Hosseini
• Genome-wide epigenetic reprogramming of the marsupial germline - Melanie K Laird
• Gonadal development and primordial germ cell migration in the fat-tailed dunnart (Sminthopsis crassicaudata) - Ebony Ciarrocchi
• Quintessential requirement of maternal PRDM10 for female fertility and successful embryonic development - Kay Yi Michelle Seah
• Exposure to diethylstilbestrol causes transgenerational effects on female fertility and reproductive development - Rachael Rogers
• MEK1/2 regulates male germline development in an FGF independent manner - Rheannon Blucher
• Impact of discrete wavelengths of light on embryo development - Darren Chow

• Sex chromosome dynamics during meiotic prophase I in the Marsupial germ line - Laia Marin-Gual
• From trash to treasure: InhaKO testis tumours produce growth factors that support SSC renewal - Penny A F Whiley
• Defining the core sperm proteome; Highly conserved targets for reproductive biology research - Taylor Pini
• Male mammalian meiosis is critically dependent on the shared functions of the katanin proteins KATNA1 and KATNAL1 - Samuel Cheers
• Importins in male germline differentiation and function: localization using Structured Illumination Microscopy - Katerina Komrskova
• Examining the developmental contributions of the phospholipidome and proteome to stage-specific oxidative stress sensitivity in the male germline - Elizabeth G Bromfield
• CEP76 is a centriole and transition zone protein required for sperm tail formation and male fertility - Brendan J Houston
• Phosphoproteomic analysis of the adaption of epididymal tissue to corticosterone challenge - David A Skerrett-Byrne

• Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth - Sigrid Petautschnig
• Placental extracellular vesicles: a novel link of preeclampsia to future cardiovascular disease   - Yourong Feng
• The lipoprotein receptor chaperone LRPAP1 is reduced in early pregnancy placenta and maternal serum from pregnancies that subsequently develop late-onset preeclampsia. - Ellen Menkhorst
• Viral mimetic-induced immune activation during periconception has adverse effects on pregnancy outcome and programs impaired immune tolerance in adult female offspring  - Stacey J Savin
• Upconversion-based Lateral Flow Assay for Sensitive Preeclampsia Detection - Sahar Masoumeh Ghorbanpour
• Prenatal alcohol exposure is associated with sex-specific alterations to placental methyl donors and reduced cerebroplacental ratio - Sarah E Steane
• Thinking outside the flock: exposure to melatonin in-utero alters twin-lamb cognition - Kelsey R Pool
• Glucocorticoid signalling and inflammatory changes in response to maternal asthma and betamethasone treatment in near-term lambs - Joshua L Robinson

• Infertile human endometrial organoid apical protein secretions are dysregulated and impair trophoblast progenitor cell adhesion - Wei Zhou
• A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation - Douglas Gibson
• Role of uterine aging in female fertility - Pradeep S Tanwar
• Human foetal reproductive organoids and their potential clinical applications - Varshini Devarapalli Venkata
• WD-repeat containing protein-61 dysregulation in the endometrial luminal epithelium impairs human endometrial receptivity - Poppy Downing
• Prevention of miscarriage in mice by boosting maternal Treg cells in pregnancy with an IL2-antibody complex - Kerrie Foyle
• Beta-defensin 22 in seminal fluid promotes female fecundability through effects on maternal receptivity to implantation in mice - Hon Y Chan
• Periconception regulatory T cell deficiency results in late gestation pregnancy pathology and susceptibility to preterm birth in mice - Jessie R Walker

Supported by:

• Reproductive Influences on Health and Ageing - Michael Garratt
• Biological Strategies to promote Tissue Repair in Regenerative Medicine - Jillian Cornish
• Bone health and fracture outcomes in the ageing population - Jackie Center
• Metabolism in ageing: cellular and physiological ageing and unravelling the riddle of the Sphinx. - Katherine Samaras

• Six-month randomised trial of open-source automated insulin delivery in Type 1 Diabetes - Mercedes J Burnside
• Association between maternal hyperglycaemia in pregnancy and offspring anthropometry in early childhood the PANDORA Wave 1 study - Angela Titmuss
• Australian and New Zealand Paediatric Surveillance Units X-linked Hypophosphataemia survey: estimate of prevalence and characteristics of paediatric X-linked Hypophosphataemia in Australia and New Zealand. - Jessica L Sandy
• What do adolescents with Type 1 Diabetes and their healthcare professionals think of a self-compassion chatbot to improve wellbeing? - Anna L Boggiss
• Dental consequences of vitamin D deficiency during pregnancy and early infancy - Deanna Beckett
• Adolescents with type 2 diabetes have poor emotional wellbeing and unmet needs in relation to their diabetes care - Dana Spajic

• Retractions in paediatric endocrinology: are we failing to regulate the literature? - Emma O'Sullivan
• Survey of Australasian clinicians to assess current care provision models and the use of genetic testing in Differences of Sex Development (DSD) - Gabby Atlas
• Does substantial preconception weight loss in women with obesity modify the epigenetic signature of the offspring? - Farrah Rodrigues
• Efficacy and safety of an open-source automated insulin delivery system over 48 weeks of use in the CREATE randomised controlled trial - Mercedes Burnside
• Diabetic ketoacidosis at onset of type 1 diabetes and long-term HbA1c in 7961 children and young adults in the Australasian Diabetes Data Network (ADDN) - Helen Clapin
• Outcomes of genomic testing for 46, XY Differences of Sex Development - Michele A O'Connell
• Which is the better newborn screening marker for classical CAH - 21 Deoxycortisol or 17α-hydroxyprogesterone? - Shubha Srinivasan
• Participant experiences of open source automated insulin delivery during the CREATE study; a 6 month randomised controlled trial. - Hamish Crocket
• Impact of oil-soluble contrast medium hysterosalpingography on thyroid function in the offspring - Divya Mathews
• Mapping the single cell transcriptome of murine adrenal glands - Lara E Graves

• Personalized modelling of human infertility with human induced pluripotent stem cells   - Amander Clark

• The prognostic value of DNA integrity assessments: An ongoing investigation.  - Róisín Griffin
• Vitrification within a nanolitre volume: oocyte and embryo cryopreservation within a 3D photopolymerised device - Megan Lim
• High-throughput sperm selection using a network of 3D microchannels - Farin Yazdan Parast

• Folic acid food fortification and pregnancy health - Claire Roberts
• Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) is disruptive for pregnancy and labouring in female mice - Kelly L Walton
• Lipopolysaccharide induced inflammation in fetal membranes can be mitigated by treatment with Angiotensin-(1-7)     - Sarah J Delforce
• Metformin has pleiotropic effects on key molecules dysregulated in placenta affected by preeclampsia - Elif Kadife

• Combined IAP inhibition with rigosertib leads to synergistic anti-tumour responses in vitro in papillary and anaplastic thyroid cancer - Shan Balachandran
• Analysis of ciclesonide, a novel glucocorticoid receptor agonist, as a potential novel treatment for the consequences of preterm birth - Rutu Dhavan
• Temporal changes in bone turnover and microarchitecture following withdrawal of RANKL inhibition - Albert S Kim
•  Epigenome-wide association study of autoimmune thyroid disease highlights novel loci - Nicole Lafontaine
• Blockade of both canonical and alternate androgen biosynthetic pathways reveals a third androgen-production pathway in mice - Ben M Lawrence
• Transcriptomic profiling of monocytes to seek a potential biomarker for primary aldosteronism - Renata Libianto

Supported by:

Lunch boxes provided for attendees to this session.

• Leydig Cell Glucocorticoid Receptor is Required to Maintain Steroidogenesis in Adulthood - Anne-Louise Gannon
• Term side-population trophoblasts can be differentiated to mature trophoblast populations and form organoids - Cherry Sun
• Chronic excess of activin A perturbs lipid profile and steroid production in the mouse gonads and adrenal gland - Jennifer C Hutchison
• Thyroglobulin antibody positivity in pregnancy does not induce maternal glucose intolerance but affects fetal sex ratio and alters markers of placental angiogenesis - Nykola L Kent
• Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure, and nuclear integrity - Samuel R Cheers
• Chemogenetic Inhibition of AgRP neurons Improves Metabolic PCOS traits in a Hyperandrogenic PCOS Mouse Model - Irene E Sucquart
• Paternal Expressed Gene 10 (PEG10) is decreased in preeclampsia - Lydia Baird
• Pattern recognition receptors as mediators of seminal fluid signalling in the female reproductive tract - Hannah E Lyons
• Assessment of the impact of Gestational and Lactation PFAS exposure on Mouse development. - Jacinta H Martin
• Examining activin and BMP signaling in human testicular cancer cell lines with emphasis on the role of nucleocytoplasmic protein IPO5 in modulating their crosstalk - Karthika Radhakrishnan
• Using a quantitative high-throughput screening platform to identify novel molecular targets and repurposable compounds for endometriosis treatment - Jacqueline F Donoghue

Lunch boxes provided for attendees to this session.

• FGF signalling is required at different times by the sexes during gonadal development - Emily Frost
• Inhibitory/Excitatory balance changes within the cerebellum in a guinea pig model of preterm birth - Carlton L Pavy
• The long-acting recombinant human follicle-stimulating hormone (SAFA-FSH) for enhancing spermatogenesis - Daham Kim
• Targeted radiotherapy induces changes to the tumour microenvironment in advanced prostate cancer - Isabel Everard
• Effects of myocyte-specific deletion on Vitamin D receptor on muscle function in mice - Miguel Lorenzo Sales Agoncillo
• Does capsaicin “beige” human white fat that has been transplanted into mice and exhibit improvements in mouse metabolism? - Sarah Davis

Lunch boxes provided for attendees to this session.

• Medullary Thyroid Cancer- new targets for imaging and challenges in treatments  - Matti Gild
• Active Surveillance Versus Immediate Surgery for Low-Risk Papillary Thyroid Microcarcinoma; Comparison of Outcomes, Quality of Life, and Medical Costs from a Multicenter Prospective Cohort Study of Korea, MAeSTro - Young Joo Park
• Molecular Profiling of Thyroid Cancer: Current and Future Developments - Roderick Clifton-Bligh

• PRC2 subunits, EZH2 and EED, have differential contributions to epigenetic programming in oocytes - Ellen Jarred
• BMP signalling facilitates meiotic progression in mouse fetal germ cells, in vivo - Fiona KM Cheung
• Mouse preimplantation embryo development in vitro requires endogenous sphingosine-1-phosphate (S1P)/S1PR signalling - Monique Rayhanna
• Epsilon tubulin is essential for spermatogenesis in the mouse wherein it regulates meiosis, sperm tail structure and nuclear remodelling - Gemma Stathatos
• Chasing their own tail: Malate dehydrogenase 1B is a testis-enriched energy protein required for progressive sperm swimming motion and male fertility.   - Tianpengcheng (Amy) Luan
• Novel insights into mouse sperm membrane proteins and surface remodelling during capacitation - Hanah M Hart

• Novel pharmacology following heteromerisation of the angiotensin II type 2 receptor and the bradykinin type 2 receptor - Elizabeth KM Johnstone
• Modulation of mineralocorticoid receptor (MR) signalling with AZD9977 for the treatment of diabetic cardiac myopathies - Monica Kanki
• Impact of oral contraception on screening for primary aldosteronism - Jun Yang
• Adrenal histopathology, adrenal vein sampling results and surgical outcomes in patients with primary aldosteronism - Kartik Sehgal

• Utility of Adrenal Vein Sampling (AVS) with and without ultra-low dose ACTH infusion - Christopher A Preston
• Enhanced user experience and reduced diabetes care burden when transitioning to calibration free sensors in advanced hybrid closed loop devices : a qualitative study - Shekhar Sehgal
• Evaluation of elevated IGF-1 in patients without clinical evidence of acromegaly - Laura Careless
• A retrospective analysis of the prevalence of hypocalcaemia and hypophosphataemia post intravenous ferric carboxymaltose and iron polymaltose in the inpatient setting - Lauren Burrage
• Assessment of the clinical utility of plasma C-telopeptide (CTX) versus N-telopeptide (NTX) of type 1 collagen in metabolic bone disease - Kirsty Fisher
• Relationship between volume and type of alcohol consumption and bone mineral density in men - Andrew Peel
• The association between asymptomatic vertebral fractures and mortality risk in older participants in CaMOS. - Jacqueline Center

2.45 PM - 3.00 PM Panel discussion

• The Psychological Impact of Trauma - Loretta White
• Trauma-informed family assessment and interventions - Anne Sinclair
• Providing trauma-informed care to children or teenagers with diabetes and their family members - Gilli Lewis

• (Ullrich)-Turner syndrome almost a century after the initial descriptions: insights that Otto and Henry could not have imagined - Charmian A Quigley
• Endocrine abnormalities in Prader Willi syndrome - Mark Harris
• Klinefelter syndrome - from birth and beyond - Penny Hunt

Supported by:

• Effect of the Polynesian-specific CREBRF gene variant on lactogenic activity during mouse pregnancy - Cameron Young
• Functional genomics for premature ovarian insufficiency: gene discoveries and patient diagnoses with clinical impact - Elena J Tucker
• Genome wide association study meta-analysis finds DENND1A, C8orf49 and XBP1 associated with lean PCOS. - Kharis Burns
• Sex dependent disruptions to the dopaminergic, GABAergic and glutamatergic systems throughout development of preterm born guinea pigs - Roisin A Moloney
• Preconception weight loss, rather than weight loss in pregnancy, improves renal outcomes in a mouse model of obesity - Natassia Rodrigo
• STAT3-independent actions of leptin on puberty onset and reproductive activity - Rebecca A Lord

• Two-sided involvement of a placenta-specific enzyme in pregnancy health - Guiying Nie
• Imaging and computational tools to assess the placenta in fetal growth restriction - Alys Clark
• In vitro 3D models of Developing Placenta - Georgia Kafer
• Circular RNAs in the placenta - Anya L Arthurs

• Endocrine sequelae of Cystic Fibrosis - Shihab Hameed
• Gut microbiome treatment - Wayne Cutfield
• Normal Puberty or Polycystic ovary Syndrome (PCOS)? - Stella Milsom
• The challenges of managing type 1 diabetes in emerging adults in Aotearoa New Zealand - Ryan Paul

• The hope, reality and challenges of conserving amphibians and reptiles through genome storage and assisted reproduction - Simon Clulow
• Breeding system and conservation management of kiwi species - Isabel Castro
• Targeting female fertility in invasive vertebrate pests using gene drives - Stephen Frankenberg
• The hybridised genome of New Zealand brushtail possum reveals novel marsupial imprinting and germline epigenetic reprogramming - Donna Bond

• Establishing positive relationships with food in toddlers and pre-school aged children - Lesley S Youde
• Body language: Promoting positive body image and relationships with food in young people with diabetes - Lotte Williams
• Detecting unhealthy relationships with food in young people with diabetes - Carmel Smart
• Nutrition strategies to support re-creating a healthy relationship with food – a case study of an inpatient encounter - Sarah Beer
• Medical management of eating disorders in adolescents and young people with diabetes - Juliet Berkeley

• Mineralocorticoid receptors in cardiovascular disease - Morag Young
• Ghrelin – cardiovascular control in health and disease - Daryl DOS Schwenke
• Circulating cardiac biomarkers linking molecular physiology and clinical outcomes - Chris J Pemberton
• Updates in lipid management - Damon Bell

• ACR TI-RADS has limited utility in a real-world setting: correlation of results and patient outcomes in a cohort presenting for thyroid ultrasonography - Tom Wilkinson
• A Clinical Decision Making Support Tool for Active Surveillance of Low Risk Papillary Thyroid Cancers - Eleanor White
• ctDNA in medullary thyroid cancer - Ayanthi Wijewardene
• Mammary-specific ablation of Cyp24a1 reduces mammary density and inhibits tumour development in MMTV-PyMT breast cancer mice - Paul H Anderson
• PMR-116, a novel inhibitor of ribosome biogenesis with antitumor activity in preclinical models of prostate cancer - Luc Furic
• Bipolar Androgen Therapy (BAT) inhibits the growth of patient-derived models of advanced prostate cancer. - Georgia Cuffe

• A mediation analysis of the effect of testosterone treatment in the T4DM trial - Gary Wittert
• Serum testosterone is inversely associated with leucocyte telomere length in men. - Bu B Yeap

Vincent Harley
FGF signalling is required at different times by the sexes during gonadal development abs# 107

Carlton L Pavy
Inhibitory/Excitatory balance changes within the cerebellum in a guinea pig model of preterm birth abs# 108

Daham Kim
The long-acting recombinant human follicle-stimulating hormone (SAFA-FSH) for enhancing spermatogenesis abs# 109

Isabel Everard
Targeted radiotherapy induces changes to the tumour microenvironment in advanced prostate cancer abs# 110

Miguel Lorenzo Sales Agoncillo
Effects of myocyte-specific deletion on Vitamin D receptor on muscle function in mice abs# 111

Sarah Davis
Does capsaicin “beige” human white fat that has been transplanted into mice and exhibit improvements in mouse metabolism? abs# 112

Christopher A Preston
Utility of Adrenal Vein Sampling (AVS) with and without ultra-low dose ACTH infusion abs# 126

Shekhar Sehgal
Enhanced user experience and reduced diabetes care burden when transitioning to calibration free sensors in advanced hybrid closed loop devices : a qualitative study abs# 127

Laura Careless
Evaluation of elevated IGF-1 in patients without clinical evidence of acromegaly abs# 128

Lauren Burrage
A retrospective analysis of the prevalence of hypocalcaemia and hypophosphataemia post intravenous ferric carboxymaltose and iron polymaltose in the inpatient setting abs# 129

Kirsty Fisher
Assessment of the clinical utility of plasma C-telopeptide (CTX) versus N-telopeptide (NTX) of type 1 collagen in metabolic bone disease abs# 130

Andrew Peel
Relationship between volume and type of alcohol consumption and bone mineral density in community dwelling men abs# 131

Aree AY Yapoudjian
The association between asymptomatic vertebral fractures and mortality risk in older participants in CaMOS. abs# 132

• Mapping of the human endometrium tissue using spatial transcriptomics  - Sharat Atluri
• Does out-of-season spawning affect smoltification in chinook salmon (Oncorhynchus tshawytscha) - Kaitlyn J Freeman
• Exploring Potential Genetic Contributions to Gender Incongruence - Vincent Harley
• A model to dissect sex differences in disease and drug response - Vincent Harley
• Discerning hormonal versus genetic contributions to sex bias in Parkinson’s Disease: the “Four Core Genotype” Rat Model - Vincent Harley
• Independent association of blood pressure with poor sleep health and shift work in the UK Biobank   - Monica Kanki
• Circulating microRNAs as predictors for dopamine agonists in hyperprolactinemic patients with pituitary adenoma - Cheol Ryong Ku
• Models of care for children newly diagnosed with Type 1 Diabetes - Ann Carrigan
• Identification of putative cortical granule proteins in zebrafish - Blake A Lewis
• Impact of long-term captivity on interrenal physiology in New Zealand shortfin eel Anguilla australis - Mia J. Milsom
• Switching on/off steroid production using light. - Diane Rebourcet
• Chronic inhibition of arcuate nucleus GABA neurons in a preclinical model of polycystic ovary syndrome - Amy Ruddenklau
• Effects of High Fat Feeding in a Novel HIF1α Mutant Mouse Line - Jenny Gunton

• Estimation of breast volume in transgender women using 2D photography: validation of the BreastIdea Volume Estimator in men and transgender women - Lachlan Angus
• Use of bicalutamide as an androgen receptor antagonist in transgender women - Lachlan Angus
• PATIENT AND PRACTITIONER EXPERIENCES OF POST-FRACTURE CARE AT THE TERTIARY-PRIMARY CARE INTERFACE: A QUALITATIVE STUDY - Michael J Bennett
• The efficacy and safety of tyrosine kinase inhibitors in advanced and metastatic thyroid cancer: A systematic review and meta-analysis of Phase III randomised controlled trials - Jessica Bindra
• Prevalence of and factors associated with dysglycaemia in adult burn inpatients - Jeffrey Chandra
• Prediction models for new fragility fracture using penalized regression and artificial intelligence in Korean women aged 50 years or older and men aged 60 years or older - Yoon-Sok (Martin) Chung
• Time-in-range: A more intuitive measure of glycemic control in type 2 diabetes than HbA1c - Vanishri Ganakumar
• The Clinical Utility of PET scanning in Medullary Thyroid Cancer - Matti L Gild
• Trabecular Bone Score declines significantly post allogeneic bone marrow transplant independent of DXA T-score - Joanna Y Gong
• Increased fracture risk in young adults with Type 1 Diabetes Mellitus (T1DM): An emerging area of need - Madhuni Herath
• Screening for primary aldosteronism in people with hyperparathyroidism: a multicentre cohort study - Annabel Jones
• Evaluating diurnal glycaemic profiles in patients with COVID-19 treated with dexamethasone: a retrospective observational study - Shejil Kumar
• Dimeric [Cys25]PTH(1-34) regulates the expression of genes related to calcium homeostasis in bone and kidney differentially from monomeric PTH(1-34) - Sihoon Lee
• Real world data of the Control IQ system in a paediatric population in a single Paediatric Diabetes Centre. - Ailsa Marshall
• Continuous glucose monitoring identifies barriers to optimal glycemic control in patients of type 2 diabetes mellitus - Madhukar Mittal
• Incidental Adrenal Masses: Incidence and Evaluation - Mitchell Munnings
• The current landscape of adrenal vein sampling in Australia - Elisabeth Ng
• Serum estradiol concentrations with estradiol 0.06% gel in transgender individuals - Brendan J Nolan
• Men with Klinefelter syndrome and idiopathic hypogonadotropic hypogonadism have deteriorated bone microstructure - Brendan J Nolan
• Does a history of Sodium-Glucose Transport-2 inhibitor use influence the diagnostic criteria used in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes A retrospective case-control study.  - Aongus O Brolchain
• Optimising DYnamic StudieS in EndocrinologY (ODYSSEY): An Endocrinology nurse initiative. - Qi Yang Damien Qi
• The Identification and Management of Adult Growth Hormone INsufficiEncy (IMAGINE):  an Endocrinology nurse initiative. - Qi Yang Damien Qi
• The association between physical activity and self-rated health status in patients with type 1 and type 2 diabetes - Tasfia TR Reza
• Do-it-yourself continuous glucose monitoring (DIY-CGM) in people with type 1 diabetes - a qualitative study - Shekhar Sehgal
• Health-related quality of life is impaired in pre-operative patients with functioning and non-functioning pituitary lesions in an Australian cohort. - Nicholas Shoung
• Growth hormone (GH) replacement therapy (GHRT) in patients with adult GH deficiency (AGHD) aged ≥60 years: data from NordiNet^® IOS and the ANSWER Program - Ana Svensson
• Investigating serum 21-deoxycortisol for therapeutic monitoring of classic congenital adrenal hyperplasia - Lauren Tyack
• After-hours management of hyperglycaemia at Hornsby Hospital: A clinical audit  - Jenny Wei
• Body fat reduction during the first year after bariatric surgery in Sri Lankan adults - Udai Wijetunga
• Variability of percentage body weight loss after bariatric surgery among Sri Lankan adults - Udai Wijetunga
• Performance of total testosterone (tT) measured using immunoassay compared with total testosterone measured by LC-MS/MS (liquid chromatography/ mass spectrometry) in the identification of women with polycystic ovary syndrome (PCOS) - Udai Wijetunga
• The utility of rested prolactin sampling in the evaluation of hyperprolactinaemia - Tom Wilkinson
• Adiposity and other factors predicting recovery of bone density at 12 months post GDM pregnancy - Ernestene Yao
• Thyroxine and advice about dairy intake in pregnant and postpartum women: misconceptions around drug counselling - Sylvia Ye
• Testosterone concentrations in men: Individual Participant Data meta-analyses from the Androgens In Men Study. - Bu B Yeap
• Hypoglycaemia in Eating Disorders - Xi May Zhen

• Durvalumab-induced hypoparathyroidism - Varun Manoharan
• Deterioration in glycaemic control in a patient with a pancreatic mass: a prompt to consider Glucagonoma - Claudia R Ashkar
• High dose phenoxybenzamine in a young patient with phaeochromocytoma and likely marijuana withdrawal: A case report - Jessica Bindra
• Polyuria and Acute Myeloid Leukaemia – an Unusual Cause of Central Diabetes Insipidus - Jessica Bindra
• Hypocalcaemia in malignancy: A case of prostate cancer with osteoblastic metastases - Jessica Bindra
• Cushioning the blow of ectopic ACTH syndrome - Lauren Burrage
• Intraoperative Surprise - A Case of a Bladder Paraganglioma - Ritoo Chowdhury
• Severe hyponatraemia with cerebral oedema after Pfizer BNT162b2 mRNA vaccination against COVID-19 - Joanna Francisca M Dharma
• Adrenal tuberculosis – an old disease worth remembering. - Bonita Duan
• Another stroke of bad luck in a case of premature ovarian insufficiency - Maritza T Farrant
• An atypical presentation for pancreatic neuroendocrine tumours and new diagnosis of Multiple Endocrine Neoplasia Type 1 with a likely pathogenic variant c.459C/G - Amelia Fernandes
• Cushing’s disease presenting as an embolic stroke in a young patient with patent foramen ovale - Emma Flaherty
• Langerhan Cell Histiocytosis following Selpercatinib use in Metastatic MTC - Matti L Gild
• Extreme catechol-O-methyltransferase pathway activity resulting in giant but silent composite phaeochromocytoma - Annabelle Hayes
• The importance of using complementary imaging modalities A case of metastatic insulinoma not identified on GA-68 DOTATATE PET - Julie T Hetherington
• SDHB mutation presenting with multifocal paraganglioma in a young woman - David Je
• Ectopic ACTH and CRH secretion as a rare cause of ACTH dependent Cushing’s - Annabel Jones
• A patient with an ectopic sphenoid bone TSH secretory adenoma  - Shejil Kumar
• Massive biochemically silent phaeochromocytoma masquerading as non-functioning adrenocortical cancer - Shejil Kumar
• Two rare cases of osteonecrosis of the external ear canal associated with denosumab use for osteoporosis - Shejil Kumar
• Primary hyperparathyroidism manifest - David Lewis
• An Illusive Source of Hypercalcaemia - Ko-Chia Jasmine Lin
• Larotrectinib in Metastatic Medullary Thyroid Carcinoma  - Ko-Chia Jasmine Lin
• Internal hernia following single anastamotic gastric bypass surgery - Varun Manoharan
• Two cases of Graves’ hyperthyroidism following Pfizer COVID vaccination - Manik Mayadunne
• Paliperidone induced hypoglycaemia a diagnostic dilemma   - Naeel Mohammad
• A case series of monogenic diabetes from Northern India showing novel variant mutations - Arunkumar R Pande
• Phaeochromocytoma presenting with vascular rupture - Yeung-Ae Park
• Successful long-term use of low dose Tolvaptan in an elderly patient for chronic Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) - Yeung-Ae Park
• Insulin pump safety in prolonged hypoglycaemia - Nayomi Perera
• Hyperfunctioning Thyroid Cancers - Mehdi Sahebol-Amri
• A management dilemma in a co-secreting Growth Hormone and Thyroid Stimulating Hormone pituitary neuroendocrine tumour. - Nicholas Shoung
• The Three Ps... Diagnosis, management and surveillance of MEN-1.   - Isobelle Smith
• Hypocalcaemia and hypophosphataemia following concurrent denosumab injection and ferric carboxymaltose infusion - Naomi Szwarcbard
• Acromegaly diagnosed 20 years after an initial presentation with symptomatic hyperprolactinaemia - Naomi Szwarcbard
• Growing weaker: a case report of the under-recognised complication of vertebral fractures in acromegaly - Brian Tran
• Metastatic medullary thyroid cancer in a young patient with neurofibromatosis 1 - Brian Tran
• Staged resection of suspected bilateral phaeochromocytoma in a patient with end-stage kidney disease on haemodialysis - Brian Tran
• Obstruction to managing a crisis - Lauren Tyack
• Polyuria polydipsia syndrome met with a rare differential diagnosis - Karen Van
• A covert case of ectopic ACTH - Tijana Vlajkovic
• Induction of lactation in a patient with complete androgen insensitivity syndrome - Kimberly Voon
• A case series of neck of femur fractures occurring in patients with type 1 diabetes and active diabetes-related foot ulcers - Kimberly Voon
• A rare case of SOX1 paraneoplastic limbic encephalitis in papillary thyroid cancer - Liyan Wang
• Cushing's disease: a bumpy course - Eleanor White
• Hyperparathyroidism-jaw tumour syndrome: diagnosis and management dilemmas - Mimi Wong
• A Rare Cause of Hypopituitarism - Sin Dee Yap

Anne-Louise Gannon
Leydig Cell Glucocorticoid Receptor is Required to Maintain Steroidogenesis in Adulthood abs# 96

Cherry Sun
Term side-population trophoblasts can be differentiated to mature trophoblast populations and form organoids abs# 97

Jennifer C Hutchison
Chronic excess of activin A perturbs lipid profile and steroid production in the mouse gonads and adrenal gland abs# 98

Nykola L Kent
Thyroglobulin antibody positivity in pregnancy does not induce maternal glucose intolerance but affects fetal sex ratio and alters markers of placental angiogenesis abs# 99

Samuel R Cheers
Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure, and nuclear integrity abs# 100

Irene E Sucquart
Chemogenetic Inhibition of AgRP neurons Improves Metabolic PCOS traits in a Hyperandrogenic PCOS Mouse Model abs# 101

Lydia Baird
Paternal Expressed Gene 10 (PEG10) is decreased in preeclampsia abs# 102

Hannah E Lyons
Pattern recognition receptors as mediators of seminal fluid signalling in the female reproductive tract abs# 103

Jacinta H Martin
Assessment of the impact of Gestational and Lactation PFAS exposure on Mouse development. abs# 104

Karthika Radhakrishnan
Examining activin and BMP signaling in human testicular cancer cell lines with emphasis on the role of nucleocytoplasmic protein IPO5 in modulating their crosstalk abs# 105

Jacqueline F Donoghue
Using a quantitative high-throughput screening platform to identify novel molecular targets and repurposable compounds for endometriosis treatment abs# 106

• How cryopreserved sperm quality is affected differently after an isolation technique is applied (DGC, swim-up, electrophoretic separation) - Alena Hungerford
• Ensembled learning for smart sperm analysis in assisted reproduction - Sahar Shahali
• Cochrane Systematic Review: Day 3 versus day 5 embryo biopsy for preimplantation genetic testing of monogenic defects - Tijana Vlajkovic
• Effect of GM-CSF on bovine in vitro oocyte maturation. - Annie Whitty

• Podocalyxin may facilitate the formation of compact and hardy spheroids in high grade serous carcinoma - Ngoc Le Tran
• Delineating cell-cell communications in testicular germ cell tumours - Sarah C Moody
• Treatment with placental EVs increased the levels of death-associated miRNAs in ovarian cancer cells - Xinyi Sun

• Expression of PCOS candidate genes in human gonadal, metabolic, and brain tissues in fetuses and adults. - Rafiatu Azumah
• Platform for genome modification in human multipotent cell line - Vincent Harley
• GM-CSF during in vitro oocyte maturation reduces reactive oxygen species levels in mouse oocytes - Anmol Saini

• In vitro embryo culture perturbs the metabolite profile and expression of genes involved in redox regulation in preimplantation embryos. - Madeleine LM Hardy

• Addressing preventable infertility through understanding ovary development and improving fertility education - Jessie M Sutherland

• Investigating steroid hormone regulation of TETs and developing a framework for hydroxymethylation studies in human endometrium - Abbey C Lissaman
• Post-natal imprinting of TH-INS in the tammar wallaby - Trent Newman

• Characterising immune function in sheep that are permanently infected with the Pestivirus border disease virus that causes Hairy Shaker disease - Laurel Quirke
• Human Seminal Fluid Extracellular Vesicles Induce Pro-Inflammatory Cytokine Responses in Female Cervical Cells In Vitro - Cottrell T Tamessar
• Comparative analysis of the origins of activin A and B in the mouse epididymis - Rukmali Wijayarathna

• Assessment of the impact of PFAS chemicals on mouse spermatozoa - Leah Calvert
• TYRO3 controls Sertoli cell proliferation and germ cell survival in the developing testis - Vincent Harley
• Elucidation of the protein composition of mouse seminal vesicle fluid - Shannon P Smyth

Developing a new method to enrich and culture marsupial spermatogonial stem cells - Patrick R S Tatt

• Utilisation of optical tweezers to probe the microenvironment of the developing oocyte - Carl Campugan
• Relationship between cumulus cell-bound BMP15 and GDF9 in fertility patients - Robert B Gilchrist
• An essential novel role for PRC2 during mouse ovarian folliculogenesis - Ellen Jarred
• Lysosomal inhibition of mouse oocytes as a model of age-related oocyte quality decline - Alexandra E Peters

• Investigation of ticagrelor as a potential therapeutic to delay preterm birth using a pipeline of in vitro, ex vivo and in vivo models of preterm birth - Bridget M Arman
• Observation of Merino ewe body condition score on lamb live weight and survival to weaning - Billie-Jaye Brougham
• Retinitis pigmentosa GTPase regulator Interacting protein 1 (RPGRIP1L) is dysregulated in placenta in fetal growth restriction - Keegan Chien
• IL-1 receptor antagonist rytvela protects against GBS-induced preterm delivery in mice. - Peck Y Chin
• Plasticity in gastric satiety signals during pregnancy and the impact of diet-induced obesity   - Georgia S Clarke
• Investigating the action of the antiplatelet agent prasugrel: offering a novel potential treatment for preeclampsia - Natasha de Alwis
• The role of mitochondria in sensing and responding to oxygen levels in the human placenta - Joshua J Fisher
• The Hidden Ingredient: Investigating the effects of ubiquitous molybdenum in placental physiology. - Vladimira Foteva
• Plasma metabolic profiling of Early-onset Preeclampsia and Fetal Growth Restriction - Luhao Han
• Associations between physical activity volume and sedentary behaviour on placental morphology throughout pregnancy - Jade Kubler
• Hyperglycaemia Modulates Insulin-regulated Aminopeptidase in Human Trophoblasts: Implications for Gestational Diabetes - Alyssa J Lochrin
• The change in body surface temperature in twin-bearing Merino ewes prior to and post-parturition - Amy L Munn
• Mucin 15 (MUC15) a cell surface associated protein is increased in preeclampsia - Anna Nguyen
• Characterising changes in small intestinal glucose absorption across the oestrous cycle in mice - Sebastian TSO Overduin
• Corticotrophin Releasing Hormone (CRH) mRNA is detectible in placental extracellular vesicles (EVs) circulating in maternal plasma - Nilanjana Paul
• MULTIOMICS APPROACH TO DIFFERENTIATE PREGNANT AND NON-PREGNANT MARES: IDENTIFICATION OF EARLY PREGNANCY PLASMA BIOMARKERS - Tharangani RW Perera
• Progression of experimental asthma during ovine pregnancy  - Andrea J Roff
• The role of progesterone on maternal behaviour and twin-lamb survival in Merino sheep - Alyce Swinbourne
• Melatonin profiles for mid and late-gestation in Merino ewes - Alyce M Swinbourne
• Differential abundance of proteins in extracellular vesicles from antiphospholipid autoantibody treated human placentae - Bridget W Tsai
• The first transcriptomic profile of epithelial gland and stromal cells from the equine endometrium - Stephanie Waugh
• The effect of elevated folic acid on placental function in vitro - Jessica Williamson
• Characterising leucine-rich repeat-containing G protein-coupled receptor 4 in the preeclamptic placenta - Georgia P Wong
• Changes in miRNA profiles in placental extracellular vesicles across gestation may contribute to maternal adaptation during pregnancy - Yi Zhang

• Elucidating the optimal level of ROS in sperm for function and fertilisation - Joshua Deluao
• Green tea extract increases mitochondrial oxidative stress and induces DNA damage in ram spermatozoa in vitro - Tayler C Kent
• Fertility of Bos indicus bull sperm in SpermSafe-B following seven days of ambient temperature storage. - Erin K Klein
• Equine fertility: Predicting the outcome of standardbred artificial inseminations using chilled semen - Ashlee Medica
• Testicular hyperthermia causes aberrant alternative splicing in round spermatids. - Benjamin R Robinson
• The role of ATP6AP2 in male fertility - Diana Vidovic

• The experiences of Endometriosis patients with diagnosis and treatment in New Zealand - Katherine Ellis
• Plasma mass spectrometry-based proteomic biomarker discovery for endometriosis - Sarah Holdsworth-Carson
• A holistic approach to managing endometriosis: what is the optimal structure and format of multidisciplinary care for endometriosis - Sarah Holdsworth-Carson
• An investigation of the plasma lipidome using a mouse model of endometriosis and pelvic pain - Sarah Holdsworth-Carson
• Extravillous trophoblast cell exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p - Gendie Lash
• The role of CD147 on the differentiation and vascular remodeling function of human extravillous trophoblast and its association with preeclampsia - Cheuk-Lun Lee
• Understanding luminal and glandular epithelial remodelling for human endometrial receptivity - Manizha Shekibi
• The Role of the Renin Angiotensin System in Decidualisation and Throughout Pregnancy - Tess L Symington
• Transcriptomic profile of the uterus during the acquisition of receptivity to embryo implantation - Ha HT Tran

• Maternal peri-conceptional macronutrient intake programs offspring nutrient targets, metabolism and behaviour - Therese Freire
• An investigation of the comparative experiences of individuals with mate kirikōpū/endometriosis and/or huahua hua kūao/polycystic ovary syndrome in Aotearoa New Zealand. - Jane E Girling
• Endometriotic chocolate cysts contain viable cells of endometrial origin: implications for endometriosis recurrence and infertility - Meaghan Griffiths
• Validation of temperature classification using remote-sensing technology during oestrous synchrony in Merino ewes - Bobbie E Lewis Baida

Emma O'Sullivan
Retractions in paediatric endocrinology: are we failing to regulate the literature? abs# 71

Gabby Atlas
Survey of Australasian clinicians to assess current care provision models and the use of genetic testing in Differences of Sex Development (DSD) abs# 72

Farrah Rodrigues
Does substantial preconception weight loss in women with obesity modify the epigenetic signature of the offspring? abs# 73

Mercedes Burnside
Efficacy and safety of an open-source automated insulin delivery system over 48 weeks of use in the CREATE randomised controlled trial abs# 74

Helen Clapin
Diabetic ketoacidosis at onset of type 1 diabetes and long-term HbA1c in 7961 children and young adults in the Australasian Diabetes Data Network (ADDN) abs# 75

Michele A O'Connell
Outcomes of genomic testing for 46, XY Differences of Sex Development abs# 76

Shubha Srinivasan
Which is the better newborn screening marker for classical CAH - 21 Deoxycortisol or 17α-hydroxyprogesterone? abs# 77

Hamish Crocket
Participant experiences of open source automated insulin delivery during the CREATE study; a 6 month randomised controlled trial. abs# 78

Divya Mathews
Impact of oil-soluble contrast medium hysterosalpingography on thyroid function in the offspring abs# 79

Lara E Graves
Mapping the single cell transcriptome of murine adrenal glands abs# 80

• Reduction In Smoking in Pregnancy A Key Contributor To Reduction In Preschool Obesity In New Zealand - Wayne S Cutfield
• The DSD clinical coordinator role: Impact on clinical care - Chloe Hanna
• The mobile food record: The usability and acceptability of image-based dietary assessment in Australian children and adolescents with type 1 diabetes. - Elizabeth Davis
• Type 1 Diabetes diluted insulin and automated insulin delivery a success story. - Niamh Howley
• Evaluation of evidence-based physical activity and exercise resources for children/teens with type 1 diabetes - Kara Mikler

• Audit of Endocrine Features in paediatric patients with Langerhans Cell Histiocytosis - Ashley Alexander
• User experience testing of a healthy lifestyle check IT application for scale of multidisciplinary programs for children and youth affected by weight issues. - Yvonne Anderson
• Prevalence of type 2 diabetes risk factors, including overweight and obesity, among youth attending hospital-based paediatric services in Western Melbourne - Eleanor Angley
• International variation in diazoxide treatment rates for neonatal hyperinsulinaemic hypoglycaemia - Eleanor Angley
• Paediatric Post-Prandial Hyperinsulinaemic Hypoglycaemia - Rosemary Brungs
• Residual beta-cell function in the first year after diagnosis in children with type 1 diabetes - Kerry Buchanan
• Duration of failure to thrive and development of obesity in children with Prader-Willi syndrome - Rachel C Debono
• Anti-GAD beyond Beta-Cells: A case of Paediatric Stiff-Person Syndrome in a person with known Type 1 Diabetes Mellitus - Rachel C Debono
• Children and adolescents with Type 1 Diabetes in New Zealand: an online survey of workforce and outcomes - Calum Fisher
•   A case of parathyroid adenoma masquerading as familial hypocalciuric hypercalcaemia. - Justin Brown
• Efficacy and safety of once-weekly somatrogon in pediatric subjects with growth hormone deficiency: lack of impact of anti-drug antibodies - Roy Gomez
• Efficacy and safety of once-weekly somatrogon vs once-daily Genotropin in Asian subjects: post-hoc subgroup analysis of the pivotal phase 3 study - Roy Gomez
• Efficacy of once-weekly somatrogon vs once-daily Genotropin in subjects stratified by peak stimulated growth hormone values (≤3, >3 to ≤6.7, and >6.7 ng/mL): post hoc analysis of the pivotal phase 3 trial - Roy Gomez
• Persistent, diazoxide-unresponsive hyperinsulinaemic hypoglycaemia in a child with Trisomy 21 - Madeleine Hall
• Characteristics at presentation of neonates with Congenital Adrenal Hyperplasia secondary to 21-hydroxylase deficiency identified on a second-tier steroid profile newborn screening programme - Madeleine Hall
• Neonatal severe hyperparathyroidism presenting with life-threatening hypercacaemia in a remote hospital treated successfully with medical and surgical management - Shihab Hameed
• Three Year Follow Up of Two Siblings Treated with IGF-1 for Growth Hormone Insensitivity Syndrome due to a Novel Mutation of Intron 4 of the Growth Hormone Receptor - Shihab Hameed
• An unusual case of 46,XY DSD with an overgrowth syndrome - Vincent Harley
• Novel Y chromosome-PML nuclear body disrupted in ATR-X syndrome model - Vincent Harley
• Novel FGF9 variant reveals a role for dimerization in sex determination - Vincent Harley
• Sirolimus as a Novel Agent for the Treatment of Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) in Children - Lucy Hastings
• Ketotic Hyperinsulinemic Hypoglycemia in a Patient with Acute Lymphoblastic Leukemia on 6-Mercaptopurine - Cindy Ho
• Denosumab for Williams syndrome associated hypercalcaemia   - Annabelle Hobbs
• Hyponatraemia in diabetic ketoacidosis (DKA) - Annabelle Hobbs
• Neonatal hypothyroidism: factors associated with the diagnosis of transient vs permanent hypothyroidism and management at a tertiary Australian centre   - Annabelle Hobbs
• Physiology of prolactin in infancy and childhood - Sarah Hosking
• Models of care for children newly diagnosed with Type 1 Diabetes - Ann Carrigan
• Transition models of care for Type 1 Diabetes: a scoping review   - Ann Carrigan
• Dominant Osteogenesis Imperfecta Caused by a Heterozygous SP7 Variant - Karissa Ludwig
• Opioid-induced adrenal insufficiency - an under-recognised phenomenon in children and adolescents - Farrah Rodrigues
• Increase in BMI SDS in youth with type 1 diabetes during the COVID-19 pandemic - Kruthika Narayan
• A virilizing ovarian tumour following previous rhabdomyosarcoma masking ovarian failure   - Farrah Rodrigues
• Extra-articular calcification in an adolescent boy: where history is paramount - Farrah Rodrigues
• Management of pancreatic agenesis in an infant: use of diabetes and telehealth technologies to overcome challenges of regional living and complex diabetes management - Jessica L Sandy
• Knowledge, safety, and impact of alcohol consumption in young adults with Type One Diabetes: a qualitative study - Oscar Sergel-Stringer
• Introduction of a gluten-free diet in children with type 1 diabetes and newly diagnosed coeliac disease increases the glycaemic index of the diet but does not adversely impact glycaemic outcomes or quality of life - Carmel E Smart
• Streamlining the review of complex hypospadias referrals at a Differences of Sex Development (DSD) multidisciplinary team meeting - Shubha Srinivasan
• Efficacy, observer-reported outcomes and safety of once-weekly somapacitan in children with growth hormone deficiency (GHD): 4-year results from the REAL 3 trial - Ana Svensson
• Once-weekly somapacitan versus daily growth hormone (GH) in children with GH deficiency (GHD): the randomised phase 3 REAL 4 trial - Ana Svensson
• Real world glycaemic outcomes in Western Australian youth with Type 1 Diabetes starting Control IQ hybrid closed loop technology - Craig E Taplin
• Prevalence and incidence of type 1 diabetes in children aged 0-14 years old in New Zealand between 2020-2021 - Rachel Wu
• A  curious case of a boy with repeated fractures - Margaret Zacharin
• Cutaneous Skeletal Hypophosphatemia Syndrome : A Case Report - Margaret Zacharin