Addressing the health conditions associated with advancing age has become a global issue, including dementia and conditions that accelerate it, such as diabetes mellitus, vascular disease and the metabolic complications associated with insulin-resistant obesity. Endocrine and metabolic factors contribute to cellular ageing, which manifests as progressive functional loss in a number of organ systems where cellular rejuvenation is limited, including neurological tissues, the beta-cell and the myocardium.
This presentation will examine the pre-clinical and clinical evidence on how metabolism contributes to ageing, the contribution of nutrient toxicity and advances in our knowledge.
For millennia, humans have been fascinated by the myth of the fountain of youth. The evidence for potential repurposing of medications that may assist in slowing cellular ageing and the effects of caloric restriction (and the myriad forms of fasting) will be discussed.