Samira Hosseini
A third-year PhD student investigating reproductive immunology
- My professional research expertise and incredible passion are in Immunology.
- I hold a bachelor’s in Medical Laboratory Sciences and a master’s in Immunology and submitted my PhD thesis in June 2022 to get graduated with a double-badge PhD degree in Immunology from Hudson Medical Research Institute, Monash University and JLU Giessen University, Germany (a joint PhD award through IRTG Program (IRTG Program: International Research Training Group).
- My PhD research project in the field of “Male Reproductive Immunology” addresses the growing appreciation of the critical roles of immune cells and immune factors through fetal testis morphogenesis; Therefore, I studied immune cells, including macrophages, T cells, mast cells, and neutrophils in human and murine fetal testis. Also, the hypothesis of the impact of activin A levels on immune cells in the murine fetal testis was tested using two mutant mouse stains with altered activin A levels (Inbha and Inha mice). In addition, neutrophils in adult human testicular germ cell tumours were investigated.
- My first paper derived from my PhD research published entitled "The changing landscape of immune cells in the fetal mouse testis and their interactions with germ cells", DOI: 10.1007/s00418-022-02129-6). My second manuscript will be submitted soon to Human Reproduction, and the third manuscript has been planned to be submitted to Andrology.
I have 7 posters presented at national and international conferences (in all, as the first author).
- My master's research project was studying immune cells in menstrual blood and peripheral blood of women with unexplained IVF failure, unexplained recurrent spontaneous abortions and unexplained fertility in the context of “Female Reproductive Immunology”. Published 4 papers as a first author: https://scholar.google.com/citations?user=Xe16bMAAAAAJ&hl=en&oi=sra
- Past experience as a medical laboratory specialist in clinical laboratories, including at Central Diagnosis Laboratory of (Golpayegan, Iran) and Newborn Screening Laboratory (Tehran, Iran).
- I have extensive experience and an in-depth understanding of fetal development of the immune system, tumour microenvironment and immune cells (macrophages (M0, M1, M2), Tregs, Th1, Th2, Th17, NK iNKT cells, mast cells and neutrophils) functions, their interactions and impacts, common and specific markers and products, their polarizations toward different phenotypes, signalling pathways, pro- and anti-inflammatory immune cell types, cytokines and chemokines, antigen-presenting cells characteristics, immune checkpoints (PD-1, CTLA-4) etc.
- Skilled in multi-colour flow cytometry, immunohistochemistry, immunofluorescence, DNA and RNA extraction methods, PCR, RT-PCR, primer design, animal handling (mice), ELISA, cell culture, microscopy, tissue fixation, embedding and cryo-sectioning, blood sampling, haematology, urinalysis, stool exams, parasitology, microbiology
- I am incredibly passionate about understanding and developing mechanisms to manipulate immune cell’s function, phenotype, interaction and impacts for inducing a pro- or anti-inflammatory microenvironment to translate new immunotherapies for the oncology setting in the laboratory and the clinic.
My professional life goal is to contribute to improved patient outcomes through my work.